DNA methylation

DNA Methylation in Candidate Genes as a Biomarker for Transgenerational Risk of Preeclampsia

Preeclampsia (PE), characterized by global fetal undernutrition due to placental insufficiency, affects over 100,000 women annually in the US. Gene-environment interactions resulting from placental insufficiency during critical developmental windows may explain differential methylation of key genes associated with familial risk of PE. In this study, our goal was to validate methylation status of CpG dinucleotides in loci of genes identified via genome-wide methylation array (Illumina Infinium) in women with and without PE (n=6/group).

Validation of DNA Methylation Patterns: Potential Biomarker for Heritable Risk of Preeclampsia

Background: Preeclampsia contributes significantly to pregnancy-associated morbidity and mortality as well as future risk of cardiovascular disease in mother and offspring, and preeclampsia in offspring.

Differential DNA Methylation in Placental and Maternal Angiogenic Genes is not Altered in Preeclampsia

Preeclampsia is a pregnancy-associated complex condition associated with inflammation, oxidative stress and angiogenic imbalance. Stress sensitive transcription factors nuclear factor-erythroid 2-like 1 (Nrf1) and nuclear factor-erythroid 2-like 2 (Nrf2) are involved in regulation of angiogenic, inflammatory and oxidative stress pathways. Recent evidence suggests a link between Nrf2 and angiogenic factor balance in preeclampsia though the degree to which maternal and placental DNA methylation contributes to disruption of Nrf pathways among women with preeclampsia is unknown.

DNA Methylation in Complex Disease: Applications in Nursing Research, Practice and Policy

DNA methylation is an epigenomic modification that is essential to normal human development and biological processes. DNA methylation patterns are heritable and dynamic throughout the life span. Environmental exposures can alter DNA methylation patterns, contributing to the development of complex disease. Identification and modulation of environmental factors influencing disease susceptibility through alterations in DNA methylation are amenable to nursing intervention and form the basis for individualized patient care.

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